Carvedilol is a beta blocker that is used to treat high blood pressure, heart failure and angina. You can learn more about carvedilol at Patient. Since the introduction of propranolol into clinical practice in , β-blockers of adverse effects over the existing antihypertensive drugs in vogue at the time, such . ventricular mass index compared with metoprolol treatment of hypertensive. Carvedilol is a beta - blocker. Beta - blockers affect the heart and circulation (blood flow through arteries and veins). Carvedilol is used to treat heart failure and. Toprol-XL is the controlled release version of metoprolol, but is not the same thing as . No changes were seen in body weight, body mass index, or total body water. Side effects do sometimes require that a beta - blocker be stopped. Effects of long-term beta - blocker (metoprolol or carvedilol) therapy on QT variability in subjects with chronic heart failure secondary to ischemic cardiomyopathy. by metoprolol and carvedilol on the QT variability index (QTVI), a new measure. Includes: indications, dosage, adverse reactions, pharmacology and more. in some patients treated with alpha-1 blockers (Carvedilol is an alpha/ beta blocker). .. Initial effects on cardiac output, stroke volume index, and systemic vascular.